Evidence map›Paper›PMID 40674409›Full record

ArticlePloS one2025

Cellular repressor of E1A-stimulated genes 1 enhances skeletal muscle performance through the stimulation of muscle differentiation and Akt-mTOR signaling pathway activation.

Ayumi Goto, Michihiro Hashimoto, Sho Yokogawa, Yuzu Naruse, Hitoshi Yamashita

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Ayumi GotoDepartment of Physiological therapy, School of Health Science, Toyohashi SOZO University, Toyohashi, Japan.ORCID https://orcid.org/0000-0001-6025-588X
Michihiro HashimotoDivision of Advanced Medical Science, Asahikawa Medical University, Asahikawa, Japan.
Sho YokogawaDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Japan.
Yuzu NaruseDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Japan.
Hitoshi YamashitaDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular repressor of E1A-stimulated genes 1 (CREG1), a glycoprotein secreted by various cell types, plays a crucial role in cellular differentiation and energy metabolism. While previous research has linked CREG1 deficiency in skeletal muscles to impaired exercise capacity and altered muscle fiber-type composition, its specific role in skeletal muscle function and differentiation remains unclear. In this study, we investigated the impact of CREG1 on muscle performance and fiber-type composition in adipocyte P2-CREG1-transgenic (Tg) mice and explored muscle differentiation in C2C12 myotubes. Tg mice exhibited significantly improved muscle performance compared to wild-type mice, as indicated by enhanced grip strength. Additionally, the proportion of type IIx fiber in the soleus muscle was significantly increased in Tg mice, along with a tendency towards elevated Myh1 mRNA expression. Enhanced CREG1 expression and activation of the Akt-mTOR signaling pathway, which is involved in muscle protein synthesis, were observed in the skeletal muscles of Tg mice. In C2C12 myotubes, Creg1 knockdown appears to decrease myoblast determination protein 1 (Myod1) expression, while recombinant CREG1 treatment restored Myod1 expression and promoted Akt-mTOR phosphorylation. These findings suggest that CREG1 stimulates muscle differentiation by enhancing protein synthesis, thereby influencing skeletal muscle function.

Indexed as

Cell DifferentiationMuscle, SkeletalProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesAnimalsCell LineMiceMice, TransgenicMuscle DevelopmentMuscle Fibers, SkeletalMyoD ProteinMyosin Heavy ChainsmTOR protein, mouseMyoD1 myogenic differentiation proteinMyoD ProteinMyosin Heavy ChainsProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinases

Identifiers

PMID40674409
PMCPMC12270121

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.