Evidence map›Paper›PMID 40674345›Full record

ArticlePloS one2025

Association of vessel density with retinal sensitivity in patients with branch retinal artery occlusion.

Rei Arasaki, Jacob Yuhang Chin, Tatsuya Inoue, Ryo Asaoka, Kazushi Hirono, Jared Ching, Shin Tanaka, Naoki Soga, Yasuo Yanagi, Maiko Maruyama-Inoue and 1 more

Abstract read
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Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Rei ArasakiDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Jacob Yuhang ChinDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Tatsuya InoueDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.ORCID https://orcid.org/0000-0002-2481-0222
Ryo AsaokaDepartment of Ophthalmology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
Kazushi HironoDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Jared ChingDepartment of Ophthalmology, Addenbrookes Hospital, Cambridge, United Kingdom.
Shin TanakaDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Naoki SogaDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Yasuo YanagiDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Maiko Maruyama-InoueDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Kazuaki KadonosonoDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the relationship between vessel density and retinal sensitivity in patients with branch retinal artery occlusion (BRAO).

methodsThis was a retrospective study of fourteen eyes of 13 BRAO patients. MP-3 microperimeter measurement and OCTA exams were performed at the same time. The exams were performed twice, one month and 6 months after the onset. The Early Treatment Diabetic Retinopathy Study (ETDRS) grid was superimposed onto the obtained images. We calculated the retinal sensitivity from MP-3 image, and vessel densities of superficial and deep capillary plexus (sVD and dVD) from OCTA images. These parameters were calculated for both the whole and parafoveal areas. A linear mixed model was used to investigate the correlations between retinal sensitivity and OCTA parameters.

resultsMean retinal sensitivity was correlated only with sVD for both the whole and parafoveal areas at the first measurement (mR2=0.337, p<;0.001 and mR2=0.314, p<;0.001, respectively, linear mixed model). A significant correlation was also observed at the second measurement. Moreover, the sVD at the first measurement was significantly associated with retinal sensitivity at the final visit for the whole area (mR2=0.364, p<;0.001) and parafoveal areas (mR2=0.341, p<;0.001).

conclusionsThe retinal sensitivity of BRAO patients was correlated with the vessel density of superficial capillary plexus at both early and late periods. The superficial vessel density at the first visit was significantly associated with retinal sensitivity at the final visit, implying that early recovery of retinal blood flow is critical for maintaining visual function in RAO eyes.

Indexed as

RetinaRetinal Artery OcclusionRetinal VesselsAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTomography, Optical CoherenceVisual Field Tests

Identifiers

PMID40674345
PMCPMC12270102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.