ArticlePloS one2025
Outcomes of medical and surgical treatment for intestinal fistulizing Crohn's disease.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Capsaicin-Triggered Vaginal Burning Due to Obstructed Rectovaginal Fistula: A Rare Case of Perineal Coproliths.The American journal of case reports · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntestinal penetrating complications of Crohn's disease (CD) are challenging issues, but it is difficult to decide between medical treatment and surgery. This study aimed to evaluate the outcomes of medical and surgical therapy in patients with non-perianal fistulizing CD.
objectiveOur study aimed to evaluate and compare the effectiveness of surgery and medical treatment in CD patients with non-perianal fistulas. MATERIALS AND
methodsThis retrospective study included all CD patients with non-perianal fistulas. We evaluated the outcomes of medical and surgical therapy. Fistula closure was identified with radiological examinations or ultrasound. Cox regression analysis was subsequently performed.
resultsSixty patients (37 male) were included. 43.3% of the patients received biological agents as the first therapy, whereas 55% required surgery as the initial therapy, and the remaining 1 patient received azathiopurine alone. 71.7% of the patients achieved fistula closure, with a median follow-up of 32 months. Among the patients who received biologics as the initial treatment, 38.5% achieved fistula closure without the need for surgery, and 50% of the patients underwent surgery. Fistula closure was observed in 69.7% of the patients who underwent surgery as the initial treatment. Enteral nutrition before initial treatment was independently associated with fistula closure.
conclusionAlthough surgery occupies a crucial role in the treatment of patients with non-perianal fistulizing CD, biologics are also effective. Enteral nutrition may increase the probability of fistula closure, especially in patients who undergo surgery as the initial therapy.
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