SynthesisWorld journal of urology2025
Which neurogenic bladder patients are at higher risk of sepsis after percutaneous nephrolithotomy?
Synthesis in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo identify predictors of sepsis following percutaneous nephrolithotomy in patients with neurogenic bladder, without investigating causal pathways.
methodsWe retrospectively analyzed a consecutive sample of patients with neurogenic bladder who underwent percutaneous nephrolithotomy at our referral center between 2009 and 2020. We also systematically searched PubMed until February 2025 for studies that investigated neurogenic patients undergoing this procedure. We then performed a single-arm meta-analysis of postoperative sepsis, including our own data, and meta-regressions to search for predictors.
resultsIn our cohort, sepsis rate was 6% [1%; 19%], 2/36 patients. The Charlson Comorbidity Index was the only predictor (p = 0.02). In the meta-cohort (13 cohorts, 2,369 patients), the combined sepsis rate was 12% [7%; 17%], despite high heterogeneity (I
conclusionWe recommend the development of a targeted antibiotic prophylaxis protocol, tailored to these predictors, for patients with neurogenic bladder undergoing percutaneous nephrolithotomy. We motivate further research on causal pathways.
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