Article in The Journal of comparative neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Sofie Ährlund-RichterThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0002-7845-7831
Jonathan HarpeThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Giselle FernandesThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Ruby LamThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0002-3077-3907
Mriganka SurThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Funding
MicroRNA mechanisms of Rett SyndromeR01MH085802 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SUR, MRIGANKA · 2010 to 2025
$6.2M
Neuron-astrocyte mechanisms of norepinephrine in goal-directed learningR01MH133066 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MRIGANKA SUR · 2023 to 2026
$2.6M
Translational Post-doctoral Training in NeurodevelopmentT32MH112510 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI DAVID C GLAHN, CHARLES Alexander NELSON · 2017 to 2026
$2.6M
Astrocyte-Neuron Circuits Underlying Cortical Mechanisms of Learned BehaviorR01NS130361 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MRIGANKA SUR · 2022 to 2026
$2.1M
Dissecting distinct contributions of different Prefrontal subregions on goal-directed visual attentionK99EY035752 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI AEHRLUND RICHTER, SOFIE · 2024 to 2025
$251k
JPB Foundation Postdoctoral FellowshipMIT Brain and Cognitive Sciences Research Scholars ProgramNEI NIH HHS K99 EY035752NIH HHS 1K99EY035752NIH HHS R01MH085802NIH HHS R01MH133066NIH HHS R01NS130361NIH HHS T32MH112510NIMH NIH HHS R01 MH085802NIMH NIH HHS R01 MH133066NIMH NIH HHS T32 MH112510NINDS NIH HHS R01 NS130361The Picower Institute Innovation FundWenner-Gren Foundation WGF2020-0019
6 · The paper itself
Abstract
Rett syndrome, a neurodevelopmental disorder caused by loss-of-function mutations in the MECP2 gene, is characterized by severe motor, cognitive, and emotional impairments. Some of the deficits may result from changes in cortical connections, especially downstream projections of the prefrontal cortex (PFC), which may also be targets of restoration following rearing conditions such as environmental enrichment that alleviate specific symptoms. Here, using a heterozygous Mecp2
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome. · full record | OpenQuestion