ArticleBrain structure & function2025
Developmental expression of α- and β- synuclein in the mouse retina.
Article in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The synuclein family comprises three presynaptic proteins-alpha-synuclein (α-Syn), beta-synuclein (β-Syn), and gamma-synuclein (γ-Syn)-which are crucial for synaptic transmission. Our previous studies have detailed the precise cellular and subcellular localization of α- and β-Syn in the adult mouse retina, revealing distinct expression patterns in excitatory and inhibitory synaptic elements. The balance between excitatory and inhibitory neurotransmitters in the inner plexiform layer (IPL) is critical for neural development in the mouse retina. Here, we employed light-microscopic immunocytochemistry to investigate the expression of α- and β-Syn in the developing mouse retina, examining from embryonic day 13.5 to postnatal day 21 (E13.5, E16.5, E19.5, P1, P7, P10, P14, and P21). We revealed distinct developmental expression patterns across these stages. We found that α-Syn was first detected at E13.5, whereas β-Syn expression appeared later at E16.5. After E16.5, β-Syn exhibited a broader expression profile compared to α-Syn. Consistent with findings in the adult retina, α-Syn was confined to inhibitory synapses, while β-Syn was present in both excitatory and inhibitory synapses during development. These unique expression patterns of α- and β-Syn in the developing retina suggest potential roles in modulating excitatory and inhibitory inputs during retinal maturation. Furthermore, this research may contribute to understanding the broader role of α- and β-Syn in neural development within the central nervous system.
Indexed as
Identifiers
40673949What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.