Evidence map›Paper›PMID 40673931›Full record

ArticleJournal of neurophysiology2025

Electroencephalogram signatures of propanidid-mediated sedation and unconsciousness.

Sirma Orguc, Ohyoon Kwon, Marusa Naranjo Gonzalez, Emery N Brown

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sirma OrgucInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.ORCID 0000-0003-2070-4171
Ohyoon KwonPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Marusa Naranjo GonzalezDepartamento de Anestesiología, Clínica de Mérida, Yucatan, Mexico.
Emery N BrownInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.ORCID 0000-0003-2668-7819

Funding

Project 4: Mathematical Modeling Studies of Anesthetic ActionP01GM118269 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, EMERY N · 2017 to 2021
$9.0M
Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery SystemsR01NS123120 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI EMERY N BROWN · 2022 to 2026
$2.0M
Bill SwansonDiane B GreeneGeorge J. ElbaumHHS | National Institutes of Health (NIH) GM118269HHS | National Institutes of Health (NIH) NS123120JPB Foundation (JPBF)Mendel RosenblumMimi JensenMIT/MGH BASCIC FundNIGMS NIH HHS P01 GM118269NINDS NIH HHS R01 NS123120Schmidt Science FellowshipThe Picower Institute of Learning and Memory
6 · The paper itself

Abstract

Propanidid is an intravenous short-acting sedative-hypnotic anesthetic in the eugenol family that acts as a positive allosteric modulator of the gamma-aminobutyric acid type A (

Indexed as

Anesthetics, IntravenousBrain WavesElectroencephalographyEugenolHypnotics and SedativesPropofolUnconsciousnessAdultAgedFemaleHumansMaleMiddle AgedAnesthetics, IntravenousEugenolHypnotics and SedativesPropofolanesthesiaEEGpropanididpropofolunconsciousness

Identifiers

PMID40673931
PMCPMC13016615

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.