Evidence map›Paper›PMID 40673828›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Oral Engineered Extracellular Vesicles Based on Ion Exchange Strategy for Multipronged Management of Wilson's Disease Complicated with Reproductive Dysfunction Therapy.

Tingting Wang, Wengui Lu, Zhifei Cheng, Luyao Wang, Zhenzhen Jiang, Yike Yue, Pengyu Jiang, Zehua Xia, Lei He, Fengying Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tingting WangDepartment of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230031, China.
Wengui LuAnhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China.
Zhifei ChengAnhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China.
Luyao WangDepartment of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230031, China.
Zhenzhen JiangDepartment of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230031, China.
Yike YueDepartment of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230031, China.
Pengyu JiangDepartment of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230031, China.
Zehua XiaDepartment of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230031, China.
Lei HeDepartment of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230031, China.
Fengying WangDepartment of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230031, China.
Limin WuCenter for Reproduction and Genetics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Qi WangAnhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China.
Hui HanDepartment of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230031, China.ORCID https://orcid.org/0009-0007-5909-8523

Funding

Anhui University of Chinese Medicine Foundation 2022rcZD001Clinical Special Translational Project of the Anhui Provincial Science and Technology Department 202204295107020044Excellent Youth Fund Project of Anhui Provincial Department of Education 2023AH030069National Natural Science Foundation of China 81673811National Natural Science Foundation of China 81971446National Natural Science Foundation of China 82374212Youth Project of Natural Science Foundation of Anhui Province 2208085QH268
6 · The paper itself

Abstract

Wilson's disease (WD), as a typical disease of excessive Cu

Indexed as

Extracellular VesiclesHepatolenticular DegenerationAdministration, OralAnimalsCopperCurcuminDisease Models, AnimalHumansMaleMiceZincCopperCurcuminZincexternal copper inhibitionintracellular copper chelationion exchange strategyneuroinflammationoral drug delivery systemwilson's disease

Identifiers

PMID40673828
PMCPMC12520522

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.