Evidence map›Paper›PMID 40673760›Full record

ArticleAntimicrobial agents and chemotherapy2025

Identification of novel compounds with prophylactic activity against hypnozoites using a

Anne-Marie Zeeman, Lars Vermaat, M Isabel Castellote Alvaro, Nicole M Van der Werff, Ivonne G Glas-Nieuwenhuis, Anke Harupa-Chung, Félix Calderón, Fransisco-Javier Gamo, Elena Fernandez Alvaro, Clemens H M Kocken

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anne-Marie ZeemanDepartment of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.ORCID 0000-0002-0157-4669
Lars VermaatDepartment of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
M Isabel Castellote AlvaroGlobal Health Medicines R&D, GSK, Madrid, Spain.
Nicole M Van der WerffDepartment of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
Ivonne G Glas-NieuwenhuisDepartment of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
Anke Harupa-ChungDepartment of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
Félix CalderónGlobal Health Medicines R&D, GSK, Madrid, Spain.
Fransisco-Javier GamoGlobal Health Medicines R&D, GSK, Madrid, Spain.
Elena Fernandez AlvaroGlobal Health Medicines R&D, GSK, Madrid, Spain.
Clemens H M KockenDepartment of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.

Funding

Tres Cantos Open Lab Foundation TCOLF TC237
6 · The paper itself

Abstract

This study aimed to identify new compounds with prophylactic activity against

Indexed as

AntimalarialsPlasmodium cynomolgiAnimalsHumansInhibitory Concentration 50LiverMalariaParasitic Sensitivity TestsAntimalarialsdrugs assayGSKhypnozoiteimage-based screeningin vitro liver stage assaymalariaphenotypic screeningplasmodium cynomolgiprophylacticTCAMS

Identifiers

PMID40673760
PMCPMC12327006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.