ArticleMicrobiology spectrum2025
Amino acid insertion in the Meq protein of Marek's disease virus, an avian oncogenic herpesvirus, accelerates tumorigenesis.
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Avian herpesvirus-specific LORF5 is a late gene, interacts with 19 viral and 111 host proteins, critical for virulence of Duck plague virus.Poultry science · 2026Article
- Virulence of Marek's disease virus in Japan is linked to polymorphisms in theThe Journal of general virology · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
Marek's disease virus (MDV) causes lymphomas (Marek's disease) in chickens. Despite vaccination, MDV field strains exhibit increased virulence, and sporadic outbreaks are still reported. An insertion/deletion in Meq has been identified in several MDV strains, and our previous study using recombinant MDV (rMDV) demonstrated that an insertion in Meq enhanced MDV virulence, whereas a deletion reduced its virulence. However, the mechanisms by which these indels in Meq alter MDV virulence remain elusive. We aimed to clarify the impact of the insertion in Meq on pathogenesis. We compared the effects of Meq and Meq with the insertion, termed L-Meq, on transcriptional regulation, the dynamics of transformed T cells and relevant T-cell subsets, and the patterns of gene expression in tumor lesions of infected chickens. Reporter assays revealed that insertion increased the transactivation activity on the infected-cell protein 4 promoter in the MDV genome and bcl-2/cd30 promoters in the host genome. rMDV encoding L-Meq (vRB-1B_L-Meq) exhibited higher mortality and tumor incidence than rMDV encoding Meq (vRB-1B_Meq), and vRB-1B_L-Meq infection increased the proportion of CD4
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