ReviewJournal of clinical neurophysiology : official publication of the American Electroencephalographic Society2025
Biomarkers for Epilepsy Deep Brain Stimulation.
Review in Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Corticocortical evoked potential amplitude is altered by cortical stimulation in epilepsy.Epilepsia · 2026Article
- Inpatient continuous thalamic stereo-electroencephalography stimulation in the evaluation of focal epilepsy: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- A comprehensive review of deep brain stimulation for drug-resistant epilepsy.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
summaryDeep brain stimulation (DBS) of the anterior nucleus of the thalamus is an FDA-approved therapy for drug-resistant focal epilepsy. Recent advances in device technology, thalamic stereotactic-EEG, and chronic sensing have deepened our understanding of corticothalamic networks in epilepsy and identified promising biomarkers to guide and personalize DBS. In this review, we examine electrophysiological, imaging, and clinical biomarkers relevant to epilepsy DBS, with a focus on their potential to support seizure detection, target engagement, network excitability tracking, and seizure risk forecasting. We highlight emerging insights from thalamic sEEG, including both passive recordings and active stimulation protocols, which enable mapping and modulation of large-scale brain networks. The capabilities of clinical sensing-enabled DBS systems are reviewed. As device functionality and biomarker discovery evolve, concerted translational efforts are needed to realize a new paradigm of personalized DBS in epilepsy.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.