ReviewJournal of bacteriology2025
The emerging role of DNA methylation in the pathogenicity of bacterial pathogens.
Review in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Lyophilization Prior to Homogenisation and Extraction Increases Membrane Protein Detection in Gram-Negative Bacterial Proteomic Analyses.Proteomes · 2026Article
- How to Unmask an Unknown: The Restriction-Modification SystemInternational journal of molecular sciences · 2026Article
- Epigenetic regulation in prokaryotes: transcriptional and phenotypic outcomes of DNA methyltransferase activity.FEMS microbiology reviews · 2026Review
- Mechanisms and therapeutic prospects of DNA methylation-mucosal innate immunity crosstalk in inflammatory bowel disease.Frontiers in immunology · 2026Review
- Antimicrobial effects of essential oil fromFrontiers in cellular and infection microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Uncovering the mechanisms regulating the pathogenicity of bacterial pathogens can help improve diagnostic capabilities and aid the development of new drugs, both of which are crucial for reducing the burden caused by bacterial infections. In recent years, with advancements in third-generation sequencing technologies, increasing evidence has shown that DNA methylation plays a pivotal role in the pathogenicity of bacterial pathogens. We believe that the key DNA methyltransferases involved in pathogenicity represent promising targets for antimicrobial therapies and that the DNA methylation sites involved in bacterial pathogenicity are important biomarkers for diagnosing bacterial infections. In this review, we summarize the following topics: (i) methods for DNA methylation sequencing; (ii) the involvement of DNA methylation in antibacterial drug resistance; (iii) the influence of DNA methylation on the expression of bacterial virulence genes; (iv) the impact of DNA methylation on bacterial biofilm formation, adhesion, and motility; and (v) the role of DNA methylation in bacterial adaptation. We hope to provide insights into bacterial pathogenicity from the perspective of bacterial epigenetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.