Evidence map›Paper›PMID 40673580›Full record

ArticleJournal of the American Heart Association2025

Effects of Intracoronary SuperSaturated Oxygen Therapy on Myocardial Blood Flow, Microvascular Obstruction, and Myocardial Salvage in ST-Segment-Elevation Myocardial Infarction in Swine Ischemia/Reperfusion Model.

Pedro H C Melo, Mateusz Kachel, Kacper Nowak, Yanping Cheng, Paul Wilburn, Donald Blum, Ramu Perumal, Jeffrey L Creech, Gilles Barone-Rochette, Robert A Kloner and 3 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pedro H C MeloSkirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.
Mateusz KachelSkirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.
Kacper NowakSkirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.ORCID 0000-0003-3782-5383
Yanping ChengSkirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.
Paul WilburnZOLL TherOx, Inc. Irvine CA USA.ORCID 0000-0002-3197-8410
Donald BlumZOLL TherOx, Inc. Irvine CA USA.
Ramu PerumalZOLL TherOx, Inc. Irvine CA USA.
Jeffrey L CreechZOLL TherOx, Inc. Irvine CA USA.
Gilles Barone-RochetteDepartment of Cardiology University Hospital Grenoble France.ORCID 0000-0002-1146-0542
Robert A KlonerDivision of Cardiovascular Medicine, Department of Medicine Keck School of Medicine of University of Southern California Los Angeles CA USA.ORCID 0000-0002-6258-0544
Juan F GranadaSkirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.ORCID 0000-0003-2399-8320
Daniel BurkhoffSkirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.ORCID 0000-0003-3995-2466
Grzegorz L KaluzaSkirball Center for Innovation Cardiovascular Research Foundation Orangeburg NY USA.ORCID 0000-0001-6915-5033

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly reperfusion after ST-segment-elevation myocardial infarction is essential for limiting infarct size. However, reperfusion injury can lead to progressive microvascular obstruction (MVO), reducing myocardial blood flow (MBF), aggravating ischemia and myocardial necrosis. We hypothesized that SuperSaturated Oxygen (SSO

methodsTwelve swine surviving 90 minutes of balloon-induced anterior ST-segment-elevation myocardial infarction and 15-minute auto-reperfusion, were assigned to 120 minutes of SSO

resultsSSO

conclusionsIn a translational ST-segment-elevation myocardial infarction model, SSO

Indexed as

Coronary CirculationMicrocirculationMyocardial Reperfusion InjuryMyocardiumOxygenOxygen Inhalation TherapyST Elevation Myocardial InfarctionAnimalsDisease Models, AnimalMaleSwineOxygenindex of microvascular resistancemicrovascular obstructionmyocardial blood flowmyocardial infarctionmyocardial salvageSuperSaturated Oxygen Therapyswine model

Identifiers

PMID40673580
PMCPMC12449960

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.