ArticleJournal of the American Heart Association2025
Endothelial Activation and Stress Index Is Associated With Adverse Maternal and Perinatal Outcomes in Preeclampsia.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Association of the Endothelial Activation and Stress Index (EASIX) and the sFlt-1/PlGF Ratio in Patients with Preeclampsia.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Endothelial Activation and Stress Index in Different Types of Hypertensive Pregnancy Disorders.Journal of the American Heart Association · 2026Article
- EASIX and Arterial stiffness in relation to nocturnal blood pressure patterns in newly diagnosed hypertension.Journal of human hypertension · 2026Article
- Longitudinal Changes in the Endothelial Activation and Stress Index (EASIX) in Patients with Preeclampsia.Diagnostics (Basel, Switzerland) · 2026Article
- The endothelial activation and stress index (EASIX) predicts hazards of short- and long-term mortality in acute ischemic stroke: a retrospective cohort study.Journal of neurology · 2026Article
- The Role of Endothelial Activation and Stress Index (EASIX) for Predicting Contrast-Induced Nephropathy and In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.Diagnostics (Basel, Switzerland) · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndothelial dysfunction represents a key driver in the development of preeclampsia. The Endothelial Activation and Stress Index (EASIX) is a validated predictor of endothelial-related complications in diverse clinical settings beyond obstetrics. Therefore, we aimed to assess the predictive performance of EASIX for adverse maternal and perinatal outcomes in pregnancies with preeclampsia.
methodsThis retrospective study analyzed data from 986 patients with preeclampsia who delivered at Heidelberg University Hospital between 2017 and 2022. The primary end points were adverse maternal (death; kidney failure; pulmonary edema; eclampsia; disseminated intravascular coagulation; hemorrhage; cerebrovascular event; and hemolysis, elevated liver enzymes, low platelets syndrome); and perinatal events (death, stillbirth, preterm delivery, placental abruption, respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis). EASIX was calculated as a product of lactate dehydrogenase and creatinine, both divided by platelet counts.
resultsFive hundred forty-two patients were eligible for the analysis. EASIX was significantly elevated in patients with a maternal adverse event (1.41±0.86 versus 0.87±0.5,
conclusionsOur findings underline EASIX as an easily available predictive marker of the risk of maternal and perinatal adverse outcomes in patients with preeclampsia. We propose that EASIX may be useful to stratify the individual risk of adverse events, especially in patients with early-onset preeclampsia.
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