Trial report in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT02361944 phase2 / phase3completednot on this map
Risk of Oxygen During Cardiac Surgery (ROCS) Trial
TypeinterventionalSponsorVanderbilt UniversityRan2016 to 2021Enrolled213ConditionsCardiac SurgeryArmsOxygen - normoxia, Oxygen - hyperoxia
Effects of Perioperative Hyperoxia Versus Normoxia on Pulmonary, Endothelial, and Inflammatory Biomarkers in Elective Laparoscopic Lower Abdominal Surgery
TypeinterventionalSponsorIstanbul UniversityRan2017 to 2019Enrolled76ConditionsHyperoxia, Perioperative Care, Oxidative Stress, Endothelial Glycocalyx InjuryArmsPerioperative Oxygen Strategy - Normoxia, Perioperative Oxygen Strategy-Hyperoxia
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Marcos G LopezDivision of Anesthesiology Critical Care Medicine, Department of Anesthesiology Vanderbilt University Medical Center Nashville TN USA.ORCID 0000-0003-2622-4267
Arvind K PandeyDivision of Cardiovascular Medicine, Department of Medicine Brigham and Women's Hospital Boston MA USA.ORCID 0000-0001-7890-4665
Cassandra HennessyDepartment of Biostatistics Vanderbilt University Medical Center Nashville TN USA.
Christopher G HughesDivision of Anesthesiology Critical Care Medicine, Department of Anesthesiology Vanderbilt University Medical Center Nashville TN USA.ORCID 0000-0002-9261-5875
Tarek S AbsiDepartment of Cardiac Surgery Vanderbilt University Medical Center Nashville TN USA.ORCID 0000-0002-6777-6132
Ashish S ShahDepartment of Cardiac Surgery Vanderbilt University Medical Center Nashville TN USA.
Matthew S ShotwellDepartment of Biostatistics Vanderbilt University Medical Center Nashville TN USA.ORCID 0000-0002-1480-0637
David G HarrisonDivision of Clinical Pharmacology, Department of Medicine Vanderbilt University Medical Center Nashville TN USA.ORCID 0000-0001-9363-6451
Frederic T BillingsDivision of Anesthesiology Critical Care Medicine, Department of Anesthesiology Vanderbilt University Medical Center Nashville TN USA.
ROCS Trial Investigators
Funding
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Training In Cardiovascular ResearchT32HL007411 · NHLBI · VANDERBILT UNIVERSITY · PI BECKMAN, JOSHUA A · 1985 to 2020
$7.2M
Investigating Functional Outcomes and Cognition thrU Surgery (InFOCUS) studyR01AG061161 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HUGHES, CHRISTOPHER, RENGEL, KIMBERLY F · 2020 to 2024
$4.6M
Pathophysiology of postoperative delirium and the use of biomimetic sleep as a treatment strategy in the CSICUR01AG053582 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JOHNSON-AKEJU, OLUWASEUN · 2016 to 2020
$4.0M
Maximizing Efficacy of Goal-Directed Sedation to Reduce Neurological Dysfunction in Mechanically Ventilated Infants and Children Study (mini-MENDS)R33HL151951 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PANDHARIPANDE, PRATIK, SMITH, HEIDI A B · 2021 to 2024
$3.4M
The INSIGHT-ICU Study: Illuminating Neuropsychological dysfunction and Systemic Inflammatory mechanisms Gleaned after Hospitalization in Trauma-ICU StudyR01GM120484 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PATEL, MAYUR B · 2017 to 2021
$3.0M
Oxygen and perioperative organ injuryR35GM145375 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Frederic Tremaine Billings · 2022 to 2026
$2.3M
The effects of soluble guanylyl cyclase stimulation on perioperative vascular reactivity and organ injury in cardiac surgery trialR01HL164909 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Marcos G Lopez · 2022 to 2026
$2.2M
Hyper-oxygenation, oxidative stress, and kidney injury following cardiac surgeryR01GM112871 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BILLINGS, FREDERIC TREMAINE · 2015 to 2019
$1.8M
Perioperative Oxygenation, Endothelial Dysfunction, and Organ Injury in Cardiac SurgeryK23GM129662 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LOPEZ, MARCOS G · 2018 to 2022
$764k
Delirium, Long-Term Cognition and the Dementia Pathological TrajectoryR21AG080420 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HUGHES, CHRISTOPHER, SANDERS, ROBERT D · 2023 to 2024
backgroundVascular dysfunction contributes to postoperative organ injury. Exposure to high concentrations of oxygen during surgery is common and may impair vascular function. We tested the hypothesis that hyperoxia during cardiac surgery impairs vascular function compared with normoxia.
methodsWe recruited and randomly assigned patients having elective cardiac surgery to hyperoxia or normoxia during surgery, measured endothelium-mediated vasodilation via brachial artery flow-mediated dilation and fingertip pulse amplitude tonometry (reactive hyperemia index), assessed endothelium-dependent, endothelium-independent, and heme-independent soluble guanylyl cyclase activator-induced vasodilation ex vivo in mediastinal fat arterioles using wire myography, and quantified plasma markers of vascular function and oxidative stress.
resultsTwo hundred participants completed the study. Oxygen treatment did not affect flow-mediated dilation (primary outcome,
conclusionsAmong adults receiving cardiac surgery, intraoperative hyperoxia did not affect endothelium-dependent vasodilation but impaired endothelium-independent vasodilation, likely via soluble guanylyl cyclase heme oxidation. Soluble guanylyl cyclase is a potential therapeutic target to enhance vascular function. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02361944.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Effects of Oxygen on Perioperative Vascular Function: A Randomized Clinical Trial. · full record | OpenQuestion