ArticleJournal of the American Heart Association2025
Comparison of Valve Academic Research Consortium (VARC)-2 and VARC-3 Criteria for Bleeding Complications After Transcatheter Aortic Valve Replacement.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Routine versus deferred percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation: a frequentist and Bayesian meta-analysis of randomized trials with trial sequential analysis.International journal of cardiology. Heart & vasculature · 2026Review
- Cardiac transthyretin amyloidosis in aortic valve replacement: RAISE score performance in the postoperative setting.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Valve Academic Research Consortium (VARC) has updated criteria for periprocedural bleeding after transcatheter aortic valve replacement. However, clinical validation of the VARC-3 bleeding definition is scarce. The aim of this study was to evaluate incidence, associated variables, and clinical impact of VARC-3 bleeding.
methodsThe study included 2227 patients with severe aortic stenosis undergoing transcatheter aortic valve replacement between 2018 and 2023 at the University Hospital Cologne. VARC-3 bleeding during the index hospitalization were analyzed. Incidence, variables associated with bleeding, and impact on 30-day mortality were evaluated by comparison to the VARC-2 criteria. All data were prospectively collected.
resultsVARC-3 bleeding was 2.5 times more prevalent than VARC-2 (13.9% versus 34.4%), as VARC-3 includes nonattributable blood loss >3 g/dL as a bleeding event. Chronic kidney disease, thoracotomy access, dual antiplatelet therapy (
conclusionsThe VARC-3 criteria present a refined classification for bleeding with prognostic relevance. However, the VARC-2 criteria demonstrate precision and clear correlation with increasing mortality risk proportional to the severity of bleeding too, showing even greater predictive accuracy in the transfemoral cohort. These findings require further validation with similar or even larger patient cohorts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.