ArticleJournal of the American Heart Association2025
Triglyceride-Glucose Index Predicts Instability in the Natural History of Intracranial Aneurysms: Insights From a Large-Scale Chinese Multicenter Cohort.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Development and validation of age- and gender-specific reference intervals for the triglyceride-glucose index in a large Chinese healthy adult population.Frontiers in endocrinology · 2026Article
- The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.Cardiovascular diabetology · 2025Review
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10 authors.
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Abstract
backgroundThe triglyceride-glucose (TyG) index is associated with various cerebrovascular diseases. However, the association between the TyG index and the instability (growth or rupture) of unruptured intracranial aneurysms (UIAs) remains underexplored.
methodsThis multicenter retrospective analysis used data from 2 prospective Chinese cohorts with UIAs. Participants with UIAs were categorized on the basis of TyG (calculated by the Ln (triglycerides [mg/dL]×fasting blood glucose [mg/dL]/2) quartiles. Kaplan-Meier survival analysis was used to estimate survival disparities among the TyG subgroups. Multivariable-adjusted Cox proportional hazards regression models and restricted cubic spline analyses were applied to assess the relationship between the TyG index and the onset of UIA instability.
resultsThis study included 5484 participants with UIAs with a median TyG index of 8.6 (interquartile range [IQR], 7.6-9.6). During a median follow-up of 57.3 (interquartile range, 50.1-67.1) months, 778 (14.2%) patients developed UIA instability. Restricted cubic spline analysis revealed a linear dose-response relationship between the TyG index and UIA instability risk. The TyG index was positively associated with risk of incident UIA instability after adjusting for potential confounding factors with adjusted hazard ratios of 1.0 (reference), 2.33 (95% CI, 1.72-3.17), 2.01 (95% CI, 2.23-4.05), and 4.39 (95% CI, 3.28-5.88) for TyG index quartiles 2, 3, and 4, respectively. Similar and consistent results were obtained in sensitivity analyses (
conclusionsThe TyG index is independently associated with a higher risk of incident UIA growth or rupture, indicating the importance of applying the index in stratifying the instability risk of UIAs.
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