Evidence map›Paper›PMID 40673490›Full record

ArticleeLife2025

Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals.

Yi Wu, Weilin Guo, Haoyue Kuang, Xiaohai Wu, Thi Huong Trinh, Yuexin Wang, Shizheng Zhao, Zilong Wen, Tao Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yi Wu *Biomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, China.ORCID https://orcid.org/0000-0002-9907-9403
Weilin Guo *Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.ORCID https://orcid.org/0000-0001-6620-2762
Haoyue KuangGreater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, China.ORCID https://orcid.org/0000-0001-6843-1788
Xiaohai WuGreater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, China.ORCID https://orcid.org/0000-0002-2569-9239
Thi Huong TrinhDivision of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.ORCID https://orcid.org/0000-0002-8799-8760
Yuexin WangGreater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, China.
Shizheng ZhaoBiomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, China.ORCID https://orcid.org/0000-0002-9859-7559
Zilong WenDivision of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.ORCID https://orcid.org/0000-0002-4260-7682
Tao YuBiomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, China.ORCID https://orcid.org/0000-0001-6017-4852

Funding

National Natural Science Foundation of China 31801211National Natural Science Foundation of Guangdong Province 2024A1515030122Research Grants Council, University Grants Committee 16103920Research Grants Council, University Grants Committee AoE/M-09/12Research Grants Council, University Grants Committee T13-602/21-NResearch Grants Council, University Grants Committee T13-605/18-WShenzhen Medical Academy of Research and Translation B2302034
6 · The paper itself

Abstract

Microglia are brain-resident macrophages playing pivotal roles in central nervous system (CNS) development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance remains largely unknown. Here, by utilizing a visible conditional knockout allele of

Indexed as

MicrogliaProto-Oncogene ProteinsTrans-ActivatorsZebrafishAnimalsMaleMammalsMiceProto-Oncogene Protein Spi-1Proto-Oncogene ProteinsProto-Oncogene Protein Spi-1Trans-Activatorscell competitiondevelopmental biologymaintenancemicrogliamousepu.1 dosageturnoverzebrafish

Identifiers

PMID40673490
PMCPMC12270482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.