Observational studyObesity (Silver Spring, Md.)2025
Grip strength: are some adiposity phenotypes more detrimental than others? A Mendelian randomization study.
Observational study in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Grip strength: are some adiposity phenotypes more detrimental than others? A Mendelian randomization study.Obesity (Silver Spring, Md.) · 2025Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveOur objective was to investigate causal associations of adiposity in different locations and metabolically favorable and unfavorable adiposity (MetFA and MetUFA, respectively) with grip strength.
methodsObservational cross-sectional and Mendelian randomization (MR) (sex combined and stratified) analysis within UK Biobank (N ≤ 340,258) was used to assess the relationships of visceral, abdominal subcutaneous, and gluteofemoral adipose tissue, anterior and posterior thigh muscle fat infiltration (ATMFI and PTMFI, respectively), body fat (BF) percentage, MetFA, and MetUFA with grip strength.
resultsIn inverse variance weighted MR analysis, SD increases in BF, MetFA, and ATMFI were associated with lower grip strength by the following: -0.10 SD (95% CI: -0.16 to -0.04), -0.31 SD (95% CI: -0.45 to -0.18), and -0.05 SD (95% CI: -0.09 to -0.01), respectively. PTMFI associations aligned with ATMFI. Observational analyses were consistent for BF and ATMFI/PTMFI, but weighted median/mode MR corroborated findings for MetFA and ATMFI/PTMFI only. Higher visceral adipose tissue was associated with lower grip strength in observational analyses only. Associations for higher abdominal subcutaneous adipose tissue were inconsistent: Observational analyses suggested weaker grip; MR analyses suggested stronger grip, particularly in female individuals. There was no strong evidence in MR for associations with MetUFA or gluteofemoral adipose tissue.
conclusionsTargeting fat infiltration in muscle may improve muscle function. MetFA appears to negatively impact muscle strength, requiring further investigation into underlying mechanisms.
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Registered trials
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