Evidence map›Paper›PMID 40673317›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[High PRELID1 expression promotes epithelial-mesenchymal transition in gastric cancer cells and is associated with poor prognosis].

Xuan Wu, Jiamin Fang, Weiwei Han, Lin Chen, Jing Sun, Qili Jin

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xuan WuDepartment of Laboratory, Second Affiliated Hospital of Bengbu Medical University, Bengbu 233080, China.
Jiamin FangDepartment of Laboratory, Second Affiliated Hospital of Bengbu Medical University, Bengbu 233080, China.
Weiwei HanDepartment of Laboratory, Second Affiliated Hospital of Bengbu Medical University, Bengbu 233080, China.
Lin ChenDepartment of Laboratory, Second Affiliated Hospital of Bengbu Medical University, Bengbu 233080, China.
Jing SunDepartment of Laboratory, Second Affiliated Hospital of Bengbu Medical University, Bengbu 233080, China.
Qili JinDepartment of Laboratory, Second Affiliated Hospital of Bengbu Medical University, Bengbu 233080, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the correlation of PRELID1 with gastric cancer (GC) progression, prognosis, and epithelial-mesenchymal transition (EMT) and the underlying mechanisms.

methodsWe analyzed the data of 115 patients undergoing radical gastrectomy for GC in our hospital between February, 2018 and March, 2023 to explore the correlation of PRELID1 expression level in GC tissues with tumor progression and patient prognosis. In cultured GC cells, the effects of lentivirus-mediated overexpression or interference of PRELID1 were observed on cell migration, invasion and EMT.

resultsImmunohistochemical staining revealed significantly higher PRELID1 expression in GC tissues (

conclusionsPRELID1 is highly expressed in GC and affects prognosis of the patients, and its high expression promotes migration, invasion and epithelial mesenchymal transition of GC cells possibly by activating the PI3K/AKT/mTOR pathway.

Indexed as

Epithelial-Mesenchymal TransitionStomach NeoplasmsCell Line, TumorCell MovementFemaleHumansMaleMiddle AgedNeoplasm InvasivenessPhosphatidylinositol 3-KinasesPrognosisProto-Oncogene Proteins c-aktSignal TransductionPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktepithelial mesenchymal transitiongastric cancerPI3K/AKT/mTORPRELID1prognosis

Identifiers

PMID40673317
PMCPMC12268903

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.