Evidence map›Paper›PMID 40673313›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

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Yunhong Yu, Wei Xie, Hui Li

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yunhong YuGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Institute of Guangdong Geriatric, Southern Medical University, Guangzhou 510080, China.
Wei XieSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Hui LiGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Institute of Guangdong Geriatric, Southern Medical University, Guangzhou 510080, China.

Funding

Natural Science Foundation for the Youth (NSFY) of China 81503564
6 · The paper itself

Abstract

objectivesTo explore the therapeutic mechanism of

methodsMale SD rat models of cognitive impairment model after epilepsy induced by intraperitoneal injection with lithium chloride and pilocarpine were randomly divided into 5 groups (

resultsCompared with those with saline treatment, the rat models treated with CHSG Decoction at 5 and 10 g/kg showed significantly shortened escape latency and prolonged stay in the target quadrant with increased number of platform crossings in Morris water maze test. CHSG Decoction treatment at the two doses significantly increased ASIC1, NR1, NR2A and NR2B protein expressions in the hippocampus of the rat models, and their mRNA expression levels were all increased significantly after the treatment at the doses above 2.5 g/kg.

conclusionsCHSG Decoction can improve cognitive impairment in rats after epilepsy possibly by regulating the expression and channel activity of NMDAR protein and its subunit protein via upregulating ASIC1 to modulate neuronal excitability and synaptic plasticity in the hippocampus.

Indexed as

Acid Sensing Ion ChannelsCognitive DysfunctionDrugs, Chinese HerbalEpilepsyHippocampusReceptors, N-Methyl-D-AspartateAnimalsMaleMaze LearningRatsRats, Sprague-DawleyUp-RegulationAcid Sensing Ion ChannelsAsic1 protein, ratDrugs, Chinese HerbalNR2B NMDA receptorReceptors, N-Methyl-D-Aspartateacid sensitive ion channelChaihu Shugan Decoctioncognitive impairmentepilepsyNMDARtreatment from Gan

Identifiers

PMID40673313
PMCPMC12268919

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.