Evidence map›Paper›PMID 40673245›Full record

ArticleRSC advances2025

Piperidine and valproic acid hybrid compound (F2S4-

Martha Cecilia Rosales Hernández, Raúl Horacio Camarillo López, Marycruz Olvera-Valdez, Leticia Guadalupe Fragoso Morales, Itzia Irene Padilla Martínez, Mónica Adriana Torres Ramos, Marycarmen Godínez Victoria, Raúl Flores Mejía, José Correa Basurto

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martha Cecilia Rosales HernándezLaboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón s/n, Casco de Santo Tomás, Distrito Federal 11340 Mexico marcrh2002@yahoo.com.mx.ORCID https://orcid.org/0000-0003-0012-580X
Raúl Horacio Camarillo LópezLaboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón s/n, Casco de Santo Tomás, Distrito Federal 11340 Mexico marcrh2002@yahoo.com.mx.
Marycruz Olvera-ValdezLaboratorio Nanomateriales Sustentables, Sección de Estudios de Posgrado e Investigación - Escuela Superior de Ingeniería Química e Industrias Extractivas, Instituto Politécnico Nacional Av. Instituto Politécnico Nacional S/N, Unidad Profesional Adolfo López Mateos CP 07708 CDMX Mexico.
Leticia Guadalupe Fragoso MoralesLaboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón s/n, Casco de Santo Tomás, Distrito Federal 11340 Mexico marcrh2002@yahoo.com.mx.
Itzia Irene Padilla MartínezLaboratorio de Química Supramolecular y Nanociencias, Unidad Profesional Interdisciplinaria de Biotecnología del Instituto Politécnico Nacional Av. Acueducto s/n Barrio la Laguna Ticomán CDMX 07340 Mexico.ORCID https://orcid.org/0000-0002-9645-2049
Mónica Adriana Torres RamosDirección de Investigación, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México and Centro de Investigación sobre el Envejecimiento, CINVESTAV sede sur. Av. Insurgentes Sur, 3877 Col. La Fama, 14269. Tlalpan Mexico.
Marycarmen Godínez VictoriaLaboratorio de Citometría de Flujo, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional CDMX Mexico.
Raúl Flores MejíaLaboratorio de Inflamación y Obesidad, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón Ciudad de México 11340 Mexico.
José Correa BasurtoLaboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotecnológica, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón s/n, Casco de Santo Tomás, Distrito Federal 11340 Mexico corrjose@gmail.com.ORCID https://orcid.org/0000-0002-4973-5265

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma and triple-negative breast cancer (TNBC) pose significant challenges in treatment due to their invasive nature and propensity for metastasis. Methotrexate (MTX) is a common chemotherapeutic agent; however, it has limited efficacy owing to its low aqueous solubility and cytostatic rather than cytotoxic effects. Valproic acid (VPA) has been used as chemotherapeutic agent, but with low potency. In this study, two novel VPA derivatives (F2S4-

Identifiers

PMID40673245
PMCPMC12266131

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.