Evidence map›Paper›PMID 40673223›Full record

ArticleChem2024

Catalyst: Systems chemistry links reactions to molecular function.

Haiyan Huang, Andrew McGrath, Christopher O Audu, Tim Cernak

Abstract read
In one paragraph

Article in Chem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Quaternary Carbons from Amines and Acids.Journal of the American Chemical Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Haiyan HuangDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, USA.
Andrew McGrathDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, USA.
Christopher O AuduDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, USA.
Tim CernakDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, USA.

Funding

New Amine-Acid Couplings and Their Impact on Medicinal PropertiesR01GM144471 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CERNAK, TIMOTHY · 2022 to 2025
$1.6M
Targeted therapy to reverse TLR4/DLL4 dysregulation in diabetic woundsF32DK126471 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AUDU, CHRISTOPHER ONORUOIZA · 2020 to 2021
$188k
NIDDK NIH HHS F32 DK126471NIGMS NIH HHS R01 GM144471
6 · The paper itself

Abstract

Andrew McGrath completed his PhD studies at the University of Michigan with Tim Cernak, studying amine-acid coupling reactions and their application in medicinal chemistry. Andrew was an undergraduate of the University of Colorado at Colorado Springs and is currently a postdoctoral researcher at Merck & Co., Inc. in Rahway, NJ. Haiyan Huang is currently a postdoctoral fellow in the Cernak Lab at the University of Michigan, where she studies amine-acid coupling reactions. She earned her BSc from Sun Yat-sen University and her PhD studying total synthesis at McGill University under the supervision of Prof. Lumb. Christopher O. Audu is currently a chief resident in vascular surgery at the University of Michigan. He studied at Purdue (BSc) and Dartmouth (MD and PhD) and performed postdoctoral research with Drs. Cernak and Gallagher at the University of Michigan. He will begin an assistant professorship of vascular surgery and chemical research at the University of Utah in the fall of 2024. Tim Cernak is an associate professor of medicinal chemistry at the University of Michigan, exploring the role of data science in chemistry and medicine in biodiversity conservation. Prior to working at the University of Michigan, he worked at Merck & Co., Inc. He is a co-founder of Iambic Therapeutics.

Identifiers

PMID40673223
PMCPMC12266709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.