Evidence map›Paper›PMID 40673140›Full record

ArticleFrontiers in microbiology2025

The potential of olfaction loss to induce cognitive impairment and anxiety behavior in mice via the microbiota-gut-brain axis.

Xiangyu Zhao, Chao Xue, Yiming Wang, Xiwei Liu, Ran Li, Xianfeng Yi

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. High frailty index scores predict mortality and changes in blood-based biomarkers in aging female mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  2. Gut Microbiome of Two Rodent Species (Animals : an open access journal from MDPI · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiangyu Zhao *School of Life Sciences, Qufu Normal University, Qufu, China.
Chao Xue *School of Life Sciences, Qufu Normal University, Qufu, China.
Yiming WangSchool of Life Sciences, Qufu Normal University, Qufu, China.
Xiwei LiuSchool of Life Sciences, Qufu Normal University, Qufu, China.
Ran LiSchool of Life Sciences, Qufu Normal University, Qufu, China.
Xianfeng YiSchool of Life Sciences, Qufu Normal University, Qufu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Olfactory dysfunction and cognition decline are frequently observed; however, very little is known about whether olfactory disorders trigger cognitive impairment. Methods: Here, we induced olfactory loss in mice and investigated whether and how olfactory loss induces cognitive impairment and anxiety behavior. Results: Olfactory loss not only causes a significant decrease in food intake and body weight and an increase in O Discussion: Our study is expected to provide some evidence for olfactory dysfunction in triggering cognitive impairment through the microbiota-gut-brain axis.

Indexed as

anxiety behaviorcognitive impairmentgut microbiotamicrobiota-gut-brain axisolfactory loss

Identifiers

PMID40673140
PMCPMC12265083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.