ReviewJournal of advanced periodontology & implant dentistry2025
Histologic evidence of the effect of fibroblast growth factor 2 on periodontal regeneration: A scoping review of animal studies.
Review in Journal of advanced periodontology & implant dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Root Cementum Molecular Structure and Its Role in Maintaining Oral Health-Systematic Review.International journal of molecular sciences · 2025Pooled it
- The Role of Biologically Active Materials in Peri-Implant Diseases.Journal of clinical medicine · 2026Review
- FGF family in health and disease.Molecular biomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Fibroblast growth factor 2 (FGF2) is a signaling molecule used successfully in periodontal regeneration. This review aims to evaluate histologic evidence of the effect of FGF2 on the regeneration of periodontal ligament (PDL), cementum, and alveolar bone in animal studies. Methods: A scoping review of the animal models was conducted to assess the histologic evidence of the effect of FGF2 on periodontal regeneration. The search was performed for English articles published until January 1, 2025. Any histologic findings regarding PDL, cementum, or bone regeneration and other outcomes such as epithelial down-growth, ankylosis, neovascularization, root resorption, and any clinical observation through histologic or radiographic analysis were considered as desired outcomes. Results: The MEDLINE and Scopus databases were searched, and 516 records were identified. After the screening, 22 articles met the inclusion criteria and were included in the study. The primary outcomes measured were any histologic findings regarding the regeneration of PDL, cementum, and alveolar bone. The included studies investigated the effect of FGF2 on the various periodontal defects, including 1-, 2-, and 3-wall vertical defects, circumferential defects, furcation involvement, and recession-type defects. In all types of defects, PDL, cementum, and alveolar bone formation were enhanced in most groups containing FGF2 compared to groups without FGF2. Most studies mentioned better radiographic results regarding bone formation or bone fill. Conclusion: FGF2 can promote regeneration in all parts of periodontal tissue in surgically created periodontal defects in animal models, including cementum, PDL, and alveolar bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.