ArticleJournal of advanced periodontology & implant dentistry2025
The association of gene polymorphisms with peri-implant mucositis and peri-implantitis: A systematic review and meta-analysis.
Article in Journal of advanced periodontology & implant dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Association of OPG, TNF-α, and IL-1B Gene Variants With Periodontitis in a South African Population.International dental journal · 2026Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The current study aimed to systematically review the existing evidence on potential links between gene polymorphisms and the occurrence of peri-implant mucositis (PIM) or peri-implantitis (PI). Methods: The electronic search was executed through six databases in November 2022: PubMed, Embase, Google Scholar, Scopus, Cochrane CENTRAL, and Web of Science. The search sought studies delving into the possible association of gene polymorphisms with PIM or PI. To showcase the effect size, odds ratios along with 95% confidence intervals were used. The meta-analysis was performed on polymorphisms/alleles reported in at least two studies. Results: The initial search yielded 2162 results, which were reduced to 1327 following deduplication. After evaluating titles, abstracts, and full texts, 30 studies were deemed suitable for inclusion. Forty-nine gene polymorphisms were examined among 50 PIM patients, 1603 PI patients, and 2407 healthy controls spanning seven ethnicities. The meta-analysis showed that IL-1α -889 (95% CI: 1.070‒2.850, OR=1.746, Conclusion: The findings suggest that IL-1α -889, IL-1β+3954, and OPG -3618 gene polymorphisms are associated with the predisposition to PI. However, further research among diverse populations is warranted to draw more definitive conclusions.
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