Evidence map›Paper›PMID 40673098›Full record

ArticleTranslational lung cancer research2025

Endoplasmic reticulum stress-related genes contribute to lung cancer risk: a multiomics data integration study.

Zhaoxun Li, Suqin Wang, Zhen Yang, Fujun Yang, Jiayan Tan, Yaqin Wei, Esteban C Gabazza, Mariacarmela Santarpia, Yimu Wu, Gening Jiang and 1 more

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Article in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Zhaoxun Li *Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Suqin Wang *Department of Clinical Laboratory, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Zhen Yang *Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Fujun Yang *Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Jiayan TanDepartment of Clinical Laboratory, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Yaqin WeiDepartment of Respiratory and Critical Care Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Esteban C GabazzaDepartment of Immunology, Faculty and Graduate School of Medicine, Mie University, Tsu, Japan.
Mariacarmela SantarpiaMedical Oncology Unit, Department of Human Pathology "G. Barresi", University of Messina, Messina, Italy.
Yimu WuDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Gening JiangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Ya LiDepartment of Laboratory Medicine, the Affiliated Hospital of Yunnan University Kunming, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The role of endoplasmic reticulum stress (ERS) in lung cancer remains inadequately explored, with existing studies reporting conflicting results. This study aimed to investigate the causal relationships between ERS-related genes and lung cancer risk. Methods: This study used two large-scale genome-wide association studies (GWAS) datasets on lung cancer and integrated multiomics data, including methylation, expression and protein quantitative trait loci, to determine the causal relationships between methylation, gene expression, protein abundance, and lung cancer risk via summary data-based Mendelian randomization (SMR) and colocalization analyses. The findings revealed regulatory effects of methylation on gene and protein expression. Moreover, using cancer databases, key genes and proteins with prognostic significance were validated, and their correlations with immune cell infiltration within the tumor microenvironment were examined. Results: We identified 168 methylation sites associated with lung cancer risk linked to 97 genes. Among these, 20 genes showed altered messenger RNA levels, and 9 had modified protein abundance. Reduced methylation at cg23090046 correlated with increased Conclusions: This study systematically investigated the causal relationship between ERS-related genes and lung cancer risk, revealing that elevated expression of

Indexed as

Endoplasmic reticulum stress (ERS)lung cancermultiomics analysissummary data-based Mendelian randomization (SMR)

Identifiers

PMID40673098
PMCPMC12261378

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