ArticleTranslational lung cancer research2025
Impact of mutant protein expression on clinical outcomes in patients with EGFR L858R-mutated non-small cell lung cancer.
Article in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Currently, patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) are typically treated with osimertinib monotherapy. However, in some patients, the therapeutic efficacy of osimertinib is suboptimal, leading to heterogeneity in treatment response, which presents a clinical challenge. It remains unclear how the expression level of EGFR-mutant protein affects osimertinib treatment and clinical outcomes. In this study, we aimed to examine the association between the expression level of EGFR L858R-mutant protein (EGFR Methods: We retrospectively assessed consecutive patients with postoperative recurrent EGFR L858R-mutated NSCLC who received osimertinib monotherapy at five hospitals in Japan between September 2018 and February 2022. Results: In total, we analyzed 23 patients with postoperative recurrent EGFR L858R-mutated NSCLC. There were no significant differences in objective response rate, progression-free survival, or overall survival for osimertinib monotherapy between the high and low EGFR Conclusions: According to our limited data (n=23), the expression level of EGFR
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