ArticleTranslational lung cancer research2025
Radiographic ground-glass nodules predict less aggressive features and favorable immune landscapes in early lung adenocarcinoma and its precursors.
Article in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Correlation between CT growth patterns and invasiveness progression in neoplastic subcentimeter sub-solid nodules.Annals of medicine · 2025Article
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8 authors.
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Abstract
Background: Lung adenocarcinoma (LUAD) remains the leading cause of cancer-related deaths globally, often due to late-stage diagnosis. Advancements in computed tomography (CT) have revolutionized the detection of indeterminate pulmonary nodules (IPNs), spanning benign lesions to early-stage LUAD. We aimed to understand early lung carcinogenesis and identify clinicopathological and immune features that may influence patient prognosis. Methods: This study retrospectively integrates clinical, radiographic, pathological, and immune data from 174 patients with resected pulmonary nodules, including atypical adenomatous hyperplasia (AAH, n=19), adenocarcinoma in situ (AIS, n=50), minimally invasive adenocarcinoma (MIA, n=40), and stage I invasive adenocarcinoma (ADC, n=65). Results: Among 174 resected nodules, ground-glass nodules (GGNs) were observed in 54.6% of all cases. Early-stage ADCs exhibited the lowest proportion of GGNs compared to AAH, AIS, and MIA, respectively (AAH: 52.6%; AIS: 86.0%; MIA: 72.5%; ADC: 20.0%; P<0.001). Well differentiated ADCs were significantly associated with lower rates of pleural traction (6.7%) and lymphovascular invasion (0%) compared to poorly differentiated ADCs (pleural traction: 36.4%, lymphovascular invasion: 18.2%). Immune profiling showed a progressive decline in CD8 Conclusions: These insights deepen our understanding of early lung carcinogenesis and offer potential pathways for prognostic stratification and personalized care for patients presenting with IPNs during CT screening.
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