Evidence map›Paper›PMID 40673059›Full record

ArticleLa matematica2025

Retinal Venous Vulnerability in Primary Open Angle Glaucoma: The Combined Effects of Intraocular Pressure and Blood Pressure with Application to the Thessaloniki Eye Study.

Rajat Rai, Giovanna Guidoboni, Christopher K Wikle, Fotis Topouzis, Brent Siesky, Alice Verticchio Vercellin, Gal Antman, Alon Harris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in La matematica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rajat RaiGraduate School of Biomedical Sciences and Engineering, University of Maine, 5775 Stodder Hall, Orono, ME 04469, USA.ORCID 0009-0008-0171-3869
Giovanna GuidoboniMaine College of Engineering and Computing, University of Maine, 5796 AMC Building, Orono, ME 04469, USA.ORCID 0000-0001-7470-0171
Christopher K WikleDepartment of Statistics, University of Missouri, 146 Middlebush Hall, Columbia, MO 65211, USA.
Fotis TopouzisDepartment of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA, Hospital, 54636 Thessaloniki, Central Macedonia, Greece.
Brent SieskyIcahn School of Medicine, Mount Sinai, 1 Gustave L Levy Pl, New York, NY 10029, USA.ORCID 0009-0006-6260-1700
Alice Verticchio VercellinIcahn School of Medicine, Mount Sinai, 1 Gustave L Levy Pl, New York, NY 10029, USA.ORCID 0000-0001-6956-905X
Gal AntmanIcahn School of Medicine, Mount Sinai, 1 Gustave L Levy Pl, New York, NY 10029, USA.
Alon HarrisIcahn School of Medicine, Mount Sinai, 1 Gustave L Levy Pl, New York, NY 10029, USA.ORCID 0000-0001-8770-3726

Funding

SCH: SEEthroughGLAUCOMA: Smart Eye Emulator (SEE) to study glaucoma risk factorsR01EY034718 · NEI · UNIVERSITY OF MAINE ORONO · PI GUIDOBONI, GIOVANNA, HARRIS, ALON · 2022 to 2025
$975k
NEI NIH HHS R01 EY034718
6 · The paper itself

Abstract

Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness with risk factors including elevated intraocular pressure (IOP), and both high and low blood pressure (BP). This study investigates the joint influence of IOP and BP on retinal hemodynamics, emphasizing venous circulation. A synthetic dataset comprising 2500 eyes with varied IOP [5-45] mmHg, systolic BP (SBP) [90-200] mmHg and diastolic BP (DBP) [40-120] mmHg was created. Mean pressure

Indexed as

Blood pressureGlaucomaIntraocular pressureMathematical modelingRetinal circulationVenous circulation

Identifiers

PMID40673059
PMCPMC12263117

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.