Evidence map›Paper›PMID 40673025›Full record

ArticleRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2025

Leptin receptor polymorphism increases the risk of painful symptoms in Brazilian women with endometriosis.

Jéssica Vilarinho Cardoso, Daniel Escorsim Machado, Fernanda Nunes de Almeida, Plínio Tostes Berardo, Rui Medeiros, Jamila Alessandra Perini

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Article in Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Jéssica Vilarinho CardosoUniversidade do Estado do Rio de Janeiro Rio de JaneiroRJ Brazil Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.ORCID https://orcid.org/0000-0002-6758-3664
Daniel Escorsim MachadoUniversidade do Estado do Rio de Janeiro Rio de JaneiroRJ Brazil Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.ORCID https://orcid.org/0000-0002-2640-8579
Fernanda Nunes de AlmeidaUniversidade do Estado do Rio de Janeiro Rio de JaneiroRJ Brazil Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.ORCID https://orcid.org/0009-0000-6075-6078
Plínio Tostes BerardoHospital Federal dos Servidores do Estado Rio de JaneiroRJ Brazil Hospital Federal dos Servidores do Estado, Rio de Janeiro, RJ, Brazil.ORCID https://orcid.org/0000-0002-4426-699X
Rui MedeirosInstituto Português de Oncologia do Porto Porto Portugal Instituto Português de Oncologia do Porto, Porto, Portugal.ORCID https://orcid.org/0000-0003-3010-8373
Jamila Alessandra PeriniUniversidade do Estado do Rio de Janeiro Rio de JaneiroRJ Brazil Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.ORCID https://orcid.org/0000-0002-7683-0698

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Endometriosis pain is associated with inflammatory cytokines, such as leptin (LEP), through activation with its receptor (LEPR), and its expression can be influenced by the presence of genetic polymorphisms. Therefore, this study aims to evaluate the role of the Methods: A retrospective study was carried out in two Brazilian public hospitals with 237 cases of endometriosis, divided into two comparison groups according to the painful symptoms associated with the disease (absence or presence of severe and disabling symptoms). Genetic analysis was performed by real-time PCR technique, and association analyses were estimated using odds ratio (OR) and 95% confidence interval (CI), using a non-conditional logistic regression model. Results: Endometriosis cases showed a high prevalence of painful symptoms: 82% dysmenorrhea, 67% dyspareunia, 53% chronic pelvic pain, and 52% cyclical intestinal and 25% urinary complaints. Regarding genetic analyses, cases had 32.7% of the A allele and 11.4% of the AA genotype for the Conclusion: Our findings suggest that the

Indexed as

EndometriosisPelvic PainPolymorphism, GeneticReceptors, LeptinAdultBrazilFemaleHumansMiddle AgedRetrospective StudiesYoung AdultLEPR protein, humanReceptors, LeptinAlellesDysmenorrheaDyspareuniaEndometriosisGenotypeInflammatory cytokinesPelvic painPolymorphism, geneticReceptors, leptin

Identifiers

PMID40673025
PMCPMC12266861

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