SynthesisFrontiers in oncology2025
Lactylation and its roles in diseases: a systematic bibliometric exploration of the research landscape.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Lactylation Remodels Tumorigenesis, Immune Microenvironment, and Therapeutic Response.Current issues in molecular biology · 2026Review
- Metabolic and post-translational modifications in sepsis-associated immune dysfunction: a conceptual framework.Frontiers in immunology · 2026Review
- Lactylation-related geneFrontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lactylation, a post-translational modification (PTM), has gained attention for its role in disease pathogenesis, particularly in cancer and immune regulation. Initially viewed as a glycolysis byproduct, lactate is now recognized as a precursor for histone lysine lactylation (Kla), which regulates gene transcription and epigenetic processes. Dysregulation of lactylation is linked to malignancies, inflammation, and metabolic diseases. Despite growing research, a systematic bibliometric analysis of lactylation remains absent. This study addresses this gap by analyzing lactylation research from 2019 to 2024, focusing on its disease-related mechanisms and therapeutic potential. Method: Data were extracted from the Web of Science Core Collection (2019-2024), yielding 198 relevant articles after screening. Bibliometric analysis was conducted using Microsoft Excel, VOSviewer, Scimago Graphica and CiteSpace. Excel tracked publication trends, VOSviewer generated author density maps, and CiteSpace visualized collaboration networks, co-cited references, and keyword clusters. Scimago Graphica generated Map of country cooperation networks. The study identified research trends, collaborative patterns, and emerging hotspots in lactylation research. Result: Lactylation research has surged exponentially since 2022, with China as the primary contributor (92.42% of publications). Dominant keywords converge on lactylation's role as a direct epigenetic regulator of gene activation, enabling transcriptional reprogramming in diseases; Lactylation drives bladder cancer progression via immunosuppressive genes, mediates myoblast differentiation for muscle repair, and disrupts signaling through non-histone targets; Emerging focus on "differentiation" and "metabolic regulation" highlights its potential as a cellular reprogramming target, crucial for advancing regenerative medicine and combating inflammation-linked pathologies. Conclusion: This study provides the first bibliometric analysis of lactylation research, highlighting its rapid growth and global significance. China leads the field, with extensive contributions from its institutions. Lactylation's role in disease mechanisms, particularly cancer and immune regulation, underscores its therapeutic potential. Emerging research on differentiation and metabolic regulation offers new directions for future studies. Further investigation into lactylation's molecular mechanisms and therapeutic applications is essential for advancing disease diagnosis and treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.