Evidence map›Paper›PMID 40672684›Full record

ArticleACS pharmacology & translational science2025

Photoactivatable Cyclometalated Ir(III) Compound Penetrates the Blood-Brain Barrier in 3D Spheroidal and Advanced 3D Organoid Models of Inherently Resistant and Aggressive Brain Tumors.

Vojtech Novohradsky, Alicia Marco, Marie Svitelova, Natalia Cutillas, José Ruiz, Viktor Brabec

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vojtech NovohradskyCzech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ-61200 Brno, Czech Republic.ORCID https://orcid.org/0000-0003-4381-8403
Alicia MarcoDepartamento de Química Inorgánica, Universidad de Murcia and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca), Murcia E-30100, Spain.ORCID https://orcid.org/0000-0002-6711-8076
Marie SvitelovaCzech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ-61200 Brno, Czech Republic.
Natalia CutillasDepartamento de Química Inorgánica, Universidad de Murcia and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca), Murcia E-30100, Spain.
José RuizDepartamento de Química Inorgánica, Universidad de Murcia and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca), Murcia E-30100, Spain.ORCID https://orcid.org/0000-0002-0834-337X
Viktor BrabecCzech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ-61200 Brno, Czech Republic.ORCID https://orcid.org/0000-0002-8233-1393

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-brain barrier represents a significant challenge in delivering anticancer drugs for glioblastoma treatment. The study investigates the potential of a series of octahedral photoactivatable cyclometalated iridium complexes (

Indexed as

3D spheroidsblood-brain barrier penetrationhuman brain glioblastomairidium complexesphotodynamic therapyROS-mediated cytotoxicity

Identifiers

PMID40672684
PMCPMC12261233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.