ArticleACS pharmacology & translational science2025
Targeting of a Bile Acid Receptor, Takeda G Protein Receptor 5 [TGR5], by a Novel First-in-Class Competitive Antagonist, SBI-364, Diminishes Hepatic and Renal Cystogenesis in Polycystic Liver and Kidney Disease.
Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Bile Acid Signaling Axis: Deciphering the Roles of FXR and TGR5 in Hepatic Steatosis, Fibrosis, and Cancer.Pharmacology research & perspectives · 2026Review
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23 authors.
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Abstract
Polycystic kidney disease (PKD) and associated polycystic liver disease (PLD) are genetic disorders with limited therapeutic options. In this work, we report SBI-364, a novel first in-class competitive antagonist of a G protein-coupled bile acid receptor, Takeda G protein receptor 5 (TGR5), as a potent small-molecule compound for concurrent treatment of both PLD and PKD. We found that elevated expression of TGR5 in hepatic epithelial cells (cholangiocytes) and renal epithelial cells (REC) from which cysts originate contributes to disease progression. To pharmacologically reduce TGR5-mediated cystogenesis, we developed a competitive TGR5 antagonist, SBI-364, and demonstrated in
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