Evidence map›Paper›PMID 40672668›Full record

ReviewACS pharmacology & translational science2025

Sigma‑2 Receptor/Transmembrane Protein 97 in Pain Modulation: Tracing Historical Roots and Current Research Directions.

Veronica M Hong, Avaneesh Rade, Amulya Bhaskara, Tarik Ehsan, See Hyun Tack, Muhammad Saad Yousuf, Stephen F Martin, Theodore J Price, Benedict Kolber

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Veronica M HongDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID https://orcid.org/0000-0002-0359-1198
Avaneesh RadeDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, United States.
Amulya BhaskaraDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, United States.
Tarik EhsanDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, United States.
See Hyun TackDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, United States.
Muhammad Saad YousufDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, United States.
Stephen F MartinDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.ORCID https://orcid.org/0000-0002-4639-0695
Theodore J PriceDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID https://orcid.org/0000-0002-6971-6221
Benedict KolberDepartment of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID https://orcid.org/0000-0001-8665-1805

Funding

Development of positive TMEM97 modulators for treating neuropathic painUG3NS131304 · NINDS · NUVONURO INC · PI MARTIN, STEPHEN · 2023 to 2023
$1.4M
Sigma 2 Receptor (TMEM97): Investigating the Peripheral Role of this Novel Therapeutic Target for PainF31NS129269 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI HONG, VERONICA MINSU · 2023 to 2025
$130k
NINDS NIH HHS F31 NS129269NINDS NIH HHS UG3 NS131304
6 · The paper itself

Abstract

The sigma-2 receptor/transmembrane protein 97 (σ

Indexed as

drug discoverypainsigma-2 receptor/Tmem97

Identifiers

PMID40672668
PMCPMC12261230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.