Evidence map›Paper›PMID 40672667›Full record

ArticleACS pharmacology & translational science2025

Targeting Casein Kinase 2 and Histone Deacetylase with a Dual Inhibitor Effectively Reduces Tumor Growth in a Triple-Negative Breast Cancer Xenograft Model.

Irene Ortín, Laura Ochoa-Callejero, Christian Werner, Dirk Lindenblatt, Karsten Niefind, Alfredo Martínez, Beatriz de Pascual-Teresa, Ana Ramos

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Irene OrtínDepartamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte 28668, Spain.
Laura Ochoa-CallejeroAngiogenesis Group, Oncology Area, Center for Biomedical Research of La Rioja (CIBIR), Logroño 26006, Spain.
Christian WernerInstitute of Biochemistry, Department of Chemistry and Biochemistry, University of Cologne, Cologne D 50674, Germany.
Dirk LindenblattInstitute of Biochemistry, Department of Chemistry and Biochemistry, University of Cologne, Cologne D 50674, Germany.
Karsten NiefindInstitute of Biochemistry, Department of Chemistry and Biochemistry, University of Cologne, Cologne D 50674, Germany.ORCID https://orcid.org/0000-0002-0183-6315
Alfredo MartínezAngiogenesis Group, Oncology Area, Center for Biomedical Research of La Rioja (CIBIR), Logroño 26006, Spain.ORCID https://orcid.org/0000-0003-4882-4044
Beatriz de Pascual-TeresaDepartamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte 28668, Spain.ORCID https://orcid.org/0000-0002-1101-0373
Ana RamosDepartamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte 28668, Spain.ORCID https://orcid.org/0000-0003-2984-4672

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a previous study,

Indexed as

CK2HDACMDA-MB-231multitarget approachxenograftX-ray crystallography

Identifiers

PMID40672667
PMCPMC12260935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.