Evidence map›Paper›PMID 40672663›Full record

ArticleACS pharmacology & translational science2025

Saliva-Activated Nanohybrid Aggregates Are Rapid-Acting Agglutination Agents with Potent Anticaries Activity and Limited Toxicity.

Kassapa Ellepola, Mohamad Khalid Alhadlaq, Angeliki Andrianopoulou, Bibash Sapkota, Heidi Yuan, Lin Chen, Richard A Gemeinhart, Robert F Klie, Matthew Lindeblad, Russell P Pesavento

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kassapa EllepolaDepartment of Oral Biology, College of Dentistry, University of Illinois Chicago, 801 S. Paulina Street, Chicago, Illinois 60612, United States.ORCID https://orcid.org/0000-0003-3806-9807
Mohamad Khalid AlhadlaqDepartment of Oral Biology, College of Dentistry, University of Illinois Chicago, 801 S. Paulina Street, Chicago, Illinois 60612, United States.
Angeliki AndrianopoulouDepartment of Pharmaceutical Sciences, College of Pharmacy,, University of Illinois Chicago, 833 S. Wood Street, Chicago, Illinois 60612, United States.
Bibash SapkotaDepartment of Physics, University of Illinois Chicago, 845 W. Taylor Street, Chicago, Illinois 60607, United States.
Heidi YuanCenter for Wound Healing and Tissue Regeneration, College of Dentistry, University of Illinois Chicago, 801 S. Paulina Street, Chicago, Illinois 60612, United States.
Lin ChenCenter for Wound Healing and Tissue Regeneration, College of Dentistry, University of Illinois Chicago, 801 S. Paulina Street, Chicago, Illinois 60612, United States.
Richard A GemeinhartDepartment of Pharmaceutical Sciences, College of Pharmacy,, University of Illinois Chicago, 833 S. Wood Street, Chicago, Illinois 60612, United States.ORCID https://orcid.org/0000-0002-1580-7304
Robert F KlieDepartment of Physics, University of Illinois Chicago, 845 W. Taylor Street, Chicago, Illinois 60607, United States.ORCID https://orcid.org/0000-0003-4773-6667
Matthew LindebladToxicology Research Laboratory, Department of Pharmacology, College of Medicine, University of Illinois Chicago, 808 S. Wood Street, Chicago, Illinois 60612, United States.
Russell P PesaventoDepartment of Oral Biology, College of Dentistry, University of Illinois Chicago, 801 S. Paulina Street, Chicago, Illinois 60612, United States.ORCID https://orcid.org/0000-0003-2599-7751

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental caries is a multifactorial process attributed to a diet high in fermentable carbohydrates, tooth-adherent plaque comprising acidogenic microbes (

Indexed as

agglutinationcarieschondroitin sulfate AnanoceriasalivaStreptococcus mutans

Identifiers

PMID40672663
PMCPMC12261236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.