ArticleAmerican journal of translational research2025
Undemineralized dentin matrix particles accelerate blood vessel formation in a critical-sized skull defect through activating the TGF-β/PI3K signaling pathway.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the effects of undemineralized dentin matrix (UDDM) particles on bone tissue regeneration and vascularization in a critical-sized skull defect (CSD) mouse model, and to elucidate the molecular mechanisms underlying UDDM extract-mediated promotion of endothelial cell proliferation, migration, and tube formation.
methodsUDDM particles and extracts were sourced from human third molars. A CSD mouse model was established, and UDDM particles were implanted into the defect site. Bone regeneration and vascularization (blood vessel volume and area) were assessed using micro-computed tomography (Micro-CT). Human umbilical vein endothelial cells (HUVECs) were treated with UDDM extract and a phosphatidylinositol 3-kinase (PI3K) inhibitor (HY-15244). Cell proliferation, migration, and tube formation were assessed. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and western blot were used to analyze the expression of transforming growth factor-beta (TGF-β)/PI3K signaling pathway-related genes and proteins.
resultsUDDM particles significantly enhanced bone formation and increased vascular volume and area in the CSD model. UDDM extract promoted HUVEC proliferation, migration, and tube formation, which were reversed by HY-15244 treatment. HY-15244 also inhibited the mRNA and protein expression of TGF-β/PI3K pathway components, which were partially rescued by UDDM extract.
conclusionUDDM particles promote bone tissue regeneration and angiogenesis in a CSD mouse model. UDDM extract facilitates proliferation, migration, and tube formation of HUVECs by activating the TGF-β/PI3K signaling pathway. These findings suggest that UDDM particles and extracts hold promise for therapeutic application in bone defect repair and vascularization.
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