ArticleAmerican journal of translational research2025
Nonlinear relationship between TyG index and the risk of non-alcoholic fatty liver disease in Chinese population: a cross-sectional study.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Diagnostic performance of TyG-related indices for MAFLD screening in older adults at moderate altitude: TyG-BMI showed the highest discriminatory ability.BMC gastroenterology · 2026Article
- Triglyceride glucose index versus triglyceride glucose-BMI index in non-alcoholic fatty liver disease: A correlation with steatosis and fibrosis.Bioinformation · 2026Article
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8 authors.
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Abstract
backgroundThere is insufficient evidence on the link between the triglyceride-glucose index (TyG) and non-alcoholic fatty liver disease (NAFLD) in the Chinese population. This study aims to investigate the association between TyG and the risk of NAFLD.
methodsA cross-sectional study was conducted with 994 participants who underwent health examinations. Demographic information, blood biochemistry profiles, and ultrasonics results were collected. Logistic regression and restricted cubic spline (RCS) analysis was used to assess the nonlinear relationship between TyG and NAFLD risk. Subgroup analysis was performed to examine possible interaction effects.
resultsOverall, 31.2% (n = 314) of the general population had NAFLD. Age, male gender, BMI, blood pressure, alanine aminotransferase, fasting blood glucose, uric acid, triglycerides and TyG levels were associated with NAFLD. RCS analysis showed a significant nonlinear dose-response relationship between TyG index and NAFLD. The risk of developing NAFLD increases significantly with a higher TyG index. This association persists even after adjustment for relevant risk factors [odds ratio (OR): 4.70, 95% CI 3.24 to 6.83]. Furthermore, compared to the lowest quartile of TyG (Q1), the NAFLD risk of subjects in the Q2, Q3, and Q4 quartiles increased 1.53, 3.84, and 16.07 times, respectively (P for trend < 0.001). Furthermore, statistically significant interactions were observed between TyG index and gender, BMI, and hypertension in predicting NAFLD risk (P < 0.05).
conclusionsThis study highlights the impact of an elevated TyG index on the risk of developing NAFLD. Elevated TyG levels may serve as a risk factor for NAFLD in the Chinese population.
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