ArticleAmerican journal of translational research2025
Chebulagic acid ameliorates DSS-induced colitis in mice by improving oxidative stress, inflammation and the gut microbiota.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Crystal engineering optimizes emodin-tetramethylpyrazine combination: From cocrystal design toInternational journal of pharmaceutics: X · 2025Article
- Rosiglitazone Ameliorates Adverse Effects of High-Fat Diet in Largemouth Bass (Antioxidants (Basel, Switzerland) · 2025Article
- Natural products targeting the MAPK signaling pathway: potential options for ulcerative colitis treatment.Frontiers in pharmacology · 2025Review
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Authors and funding
7 authors.
Funding
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Abstract
objectivesChebulagic acid (CA), isolated from the fruits of
methodsThe mouse model of DSS-induced acute colitis was employed to evaluate the effect of CA on UC. The expression of pro-inflammatory cytokines and tight junction proteins were evaluated by quantitative real-time PCR (qRT-PCR). Western blotting was used to explore the potential signal pathway. The gut microbiota was analyzed by 16S rDNA amplicon sequencing.
resultsThe data showed that CA significantly mitigated colitis severity, as manifested by the suppression of weight loss, shortening of colon, disease activity index (DAI) and histopathological score. CA increased superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity and reduced malondialdehyde (MDA) content in the colon of colitis mice through inhibiting the mitogen-activated protein kinase (MAPK) pathway and the activating nuclear respiratoty factor 2 (NRF2)/heme oxygenase-1 (HO-1) pathway. Meanwhile, myeloperoxidase (MPO) activity and proinflammatory cytokines levels of the CA group were markedly decreased due to suppression of the nuclear factor kappa-B (NF-κB) signaling pathway. Moreover, CA could upregulate the expression of tight junction proteins and reduced apoptosis. Furthermore, CA remodeled the gut microbiota through suppressing the growth of harmful bacteria (
conclusionsThis study revealed that CA treatment could ameliorate DSS-induced acute colitis mainly via reducing oxidative stress and inflammation, maintaining the integrity of the intestinal barrier and modulating diversity and abundance of gut microbiota; thus, CA may become a promising novel drug candidate for initial and maintenance therapy of UC.
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