ReviewAmerican journal of translational research2025
Efficacy and safety of oral anticoagulants in elderly patients with non-valvular atrial fibrillation: a meta-analysis.
Review in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThromboembolism is a common complication in elderly patients with non-Valvular Atrial Fibrillation (NVAF). Noval oral anticoagulants (NOACs) remain the primary treatment strategy. This study focuses on the optimal dosage and safety of new oral anticoagulants introduced in recent years.
objectiveTo investigate the optimal dose and safety of NOACs in elderly patients with NVAF through meta-analysis.
methodsA systematic literature search was conducted using both Chinese and international academic databases to identify studies on NOAC therapy in elderly patients with NVAF. A total of 22 studies were included. Meta-analysis was performed using RevMan 5.3 software.
resultsThe risk of systemic embolism (SSE) in patients receiving warfarin was significantly higher compared to those on both standard-dose and low-dose NOACs. Patients who take conventional doses of new anticoagulants orally have a higher risk of developing SSE (P < 0.05). The risk of severe bleeding in patients receiving standard-dose warfarin was higher than those on conventional dose and low-dose NOACs. There was no statistically significant difference in the risk of severe bleeding between patients with conventional and low-dose anticoagulants (P > 0.05). Funnel plots for SSE and major bleeding outcomes were symmetrical and centered around the mean, suggesting low publication bias and reliable results.
conclusionLow-dose NOACs demonstrate favorable efficacy and safety in elderly NVAF patients, appearing superior to warfarin and conventional dose NOACs. These findings support the preferential use of NOACs over warfarin in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.