Evidence map›Paper›PMID 40672514›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Risk and protective factors against cognitive decline in older adults from a nationally representative sample in India: Results from the LASI-DAD.

Alden L Gross, Emma Nichols, Miguel Arce Rentería, Pranali Y Khobragade, Erik Meijer, Mary Ganguli, Eileen M Crimmins, Sharmistha Dey, Aparajit Ballav Dey, Jinkook Lee and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Alden L GrossDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E, Monument St., Baltimore, Maryland, USA 21231.
Emma NicholsCenter for Economic and Social Research, University of Southern California, 635 Downey Way, VPD, Los Angeles, California, USA 90089.
Miguel Arce RenteríaTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, 710 W 168th St #3, New York City, NY, USA 10032.
Pranali Y KhobragadeCenter for Economic and Social Research, University of Southern California, 635 Downey Way, VPD, Los Angeles, California, USA 90089.
Erik MeijerCenter for Economic and Social Research, University of Southern California, 635 Downey Way, VPD, Los Angeles, California, USA 90089.
Mary GanguliDepartment of Psychiatry, Neurology, and Epidemiology, University of Pittsburgh School of Medicine and School of Public Health, 3550 Terrace St, Pittsburgh, Pennsylvania, USA 15213.
Eileen M CrimminsLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, California, USA 90089.
Sharmistha DeyDepartment of Biophysics, All India Institute of Medical Sciences, Benito Juarez Road,South Campus, South Moti Bagh, South Campus, South Moti Bagh, New Delhi, India 110021.
Aparajit Ballav DeyVenu Geriatric Institute, Sheikh Sarai, New Delhi, India 110017.
Jinkook LeeCenter for Economic and Social Research, University of Southern California, 635 Downey Way, VPD, Los Angeles, California, USA 90089.
LASI-DAD Authorship Team

Funding

Integrting Information About Aging SurveysR01AG030153 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sara Adar, Alden L. Gross · 2007 to 2026
$41.7M
Leveraging a natural experiment to estimate the causal impact of blood sugar on dementia and cognition in IndiaR01AG051125 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jinkook Lee · 2015 to 2026
$26.8M
USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE · 1999 to 2026
$17.9M
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.U01AG064948 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KARDIA, SHARON L, LEE, JINKOOK · 2019 to 2023
$12.5M
Socioeconomic, Cardiovascular, and Psychosocial Sources of Cross-National Variation in Cognitive Health Among Older AdultsR01AG070953 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alden L. Gross, Lindsay C Kobayashi · 2021 to 2026
$4.6M
Biomarkers of neurodegeneration in the US and India: A cross-national evaluation of the biological underpinnings of ADRDRF1AG088003 · NIA · JOHNS HOPKINS UNIVERSITY · PI CRIMMINS, EILEEN M, GROSS, ALDEN L. · 2024 to 2024
$2.4M
NIA NIH HHS P30 AG017265NIA NIH HHS R01 AG030153NIA NIH HHS R01 AG051125NIA NIH HHS R01 AG070953NIA NIH HHS RF1 AG088003NIA NIH HHS U01 AG064948
6 · The paper itself

Abstract

introductionWe characterized modifiable risk and protective factors for cognitive decline in India.

methodsUsing the first nationally representative population-based longitudinal sample of N=6,168 older adults in India, we evaluated associations of risk factors (demographic characteristics, self-reported and objective health characteristics, health behaviors, and sensory function) for late-life cognitive decline with up to 6.4 years of follow-up (range: 2.8 to 6.4 years).

resultsThe mean rate of general cognitive decline was -0.029 SD per year, and was progressively steeper with age. Most risk factors, particularly demographic and cardiovascular characteristics, were associated with steeper cognitive decline in expected directions: associations of history of high cholesterol or heart attack on rate of cognitive decline, for example, were comparable to being 11-12 years older. DISCUSSION: Most risk factors were associated with change in expected directions, highlighting the potential generalizability to India of previously identified risk factors for dementia.

Indexed as

cognitive declinegerontologyHCAPIndiaLASI-DAD

Identifiers

PMID40672514
PMCPMC12265744

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.