In one paragraphArticle in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
37 authors.
Laurel ScrevenGlobal Parkinson's Genetics Program (GP2), Maryland, USA.
Ai Huey TanDivision of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.ORCID 0000-0002-2979-3839 Roy N AlcalayNeurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Department of Neurology, Columbia Irving Medical School, New York, NY, USA.ORCID 0000-0002-5717-4875 Roberta BovenziNeurology Unit, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.ORCID 0009-0004-4824-0051 Matilda FennDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Joshua L I FrostDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Joseph JankovicParkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-4129-3674 Simona JasaityteDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID 0009-0009-6030-2901 Zane JaunmuktaneDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0001-7738-8881 Ignacio Juan Keller SarmientoDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0003-0979-6001 Lukas PavelkaLuxembourg Institute of Health (LIH), Strassen, Luxembourg and Centre Hospitalier de Luxembourg (CHL), Luxembourg.ORCID 0000-0002-7721-3317 Maria Teresa PeriñanCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.
Tommaso SchirinziNeurology Unit, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.ORCID 0000-0002-2517-6278 Jung Hwan ShinDepartment of Neurology, Seoul National University Hospital, Seoul, South Korea.
Joshua M ShulmanParkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
Yi Wen TayDivision of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.ORCID 0000-0002-9319-0768 Tom WarnerDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0002-2648-4264 Lesley WuDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0001-5464-5603 Ruey-Meei WuDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Kirsten E ZeunerUniversity Hospital Schleswig-Holstein (UKSH), Campus Kiel, Kiel, Germany.
Niccolò E MencacciDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0003-3383-9665 Huw R MorrisDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0002-5473-3774 Shen-Yang LimDivision of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.ORCID 0000-0002-6942-2522 Katja LohmannInstitute of Neurogenetics, University of Luebeck, Luebeck, Germany.
Funding
Genome wide SNP analysis in Parkinson's diseaseZIAAG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW · 2009 to 2024
$12.6MGenome wide SNP analysis in Parkinson's diseaseZ01AG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW B · 2006 to 2008
$2.6MMIDCAREER AWARD IN PATIENT ORIENTED RESEARCH ON AGINGK24AG000949 · NIA · YALE UNIVERSITY · PI INOUYE, SHARON K. · 1999 to 2009
$1.4MIntramural NIH HHS Z01 AG000949Intramural NIH HHS ZIA AG000949NIA NIH HHS K24 AG000949
6 · The paper itselfAbstract
Background: Dystonia and Parkinson's disease (PD) show clinical and genetic overlap, but the relevance of dystonia gene variants in PD remains unclear. Objective: To assess the frequency of dystonia-linked pathogenic variants in PD. Methods: We screened sequencing data from 15,738 individuals (7,851 PD, 4,287 atypical parkinsonism, and 3,600 unaffected) from GP2 and AMP-PD for variants in genes linked to isolated dystonia, dystonia-parkinsonism, and myoclonus-dystonia. Results: Pathogenic variants were only identified in PD patients. Forty-five PD individuals (0.57%) carried 26 distinct (likely) pathogenic variants in nine dystonia-linked genes, most frequently in Conclusion: Though rare, pathogenic variants in dystonia-linked genes are present in clinically and pathologically diagnosed PD. Our results reinforce
Indexed as
DystoniaGCH1MonogenicParkinson’s diseaseVPS16
Identifiers
PMID40672488
PMCPMC12265777
What OpenQuestion holds
Textmetadata
LicenceCC BY
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