ArticlemedRxiv : the preprint server for health sciences2025
Associations of
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated byAssociations of2026
Authors and funding
33 authors.
Funding
Abstract
introductionWe investigated the presence of neurofibrillary tangles (NFT) and their association with amyloid plaques and fluid biomarkers of Alzheimer's disease (AD) in cognitively unimpaired individuals (CU).
methodsNinety-nine CU individuals from the ALFA+ cohort underwent tau PET using
resultsNine cases were Braak-I/II positive, five Braak-III/IV, and one Braak-V/VI. For CSF biomarkers, the strongest associations with Braak-I/II reached r=0.58 [95%CI:0.26-0.79, p<0.001, CSF ptau217] and, for plasma, r=0.25 [95%CI:0.03-0.45, p=0.01, plasma ptau181/Aβ42], but showed low PPVs [0.09-0.33] for Braak-I/II positivity. DISCUSSION:
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.