Evidence map›Paper›PMID 40672444›Full record

SynthesisFrontiers in molecular neuroscience2025

Recognition of the microbial metabolite

María Isabel Serrano-Tomás, Paulina Contreras-Romero, Mara Parellada, Javier Chaves-Cordero, Javier Zamora, Martha Hengst, Patricia Pozo, Rosa Del Campo, Sheyla Guzmán-Salas

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. ACS pharmacology & translational science · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

María Isabel Serrano-TomásServicio de Microbiología, Hospital Universitario Ramón y Cajal, and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
Paulina Contreras-RomeroDepartamento de Ciencias Farmacéuticas, Universidad Católica del Norte, Antofagasta, Chile.
Mara ParelladaServicio de Psiquiatría del Niño y del Adolescente, Facultad de Medicina, Centro de Investigación en Red en Salud Mental (CIBERSAM), Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Instituto de Psiquiatría y Salud Mental, Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain.
Javier Chaves-CorderoServicio de Medicina Preventiva y Salud Pública, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Javier ZamoraUnidad de Bioestadística, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria and Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Martha HengstDepartamento de Ciencias Farmacéuticas, Universidad Católica del Norte, Antofagasta, Chile.
Patricia PozoDepartamento de Ciencias Farmacéuticas, Universidad Católica del Norte, Antofagasta, Chile.
Rosa Del CampoServicio de Microbiología, Hospital Universitario Ramón y Cajal, and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
Sheyla Guzmán-SalasDepartamento de Ciencias Farmacéuticas, Universidad Católica del Norte, Antofagasta, Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In recent years, research has focused on the gut-brain axis and its microbial metabolites as potential etiological or physiopathological agents of autism spectrum disorders (ASDs). Elevated levels of the organic compound Methods: A search was performed in the PubMed, Web of Science and Scopus databases in May 2024. The Axis critical appraisal tool was used to evaluate the methodological quality of the studies included in the review. Three independent reviewers examined the identified records and performed data extraction. Results: The systematic review yielded 15 articles, of which only 6 were ultimately used for the meta-analysis. Urinary Conclusion: This meta-analysis validates that in ASD an increased level of

Indexed as

autism spectrum disordergut-brain axismetabolitesmicrobiomep-cresol

Identifiers

PMID40672444
PMCPMC12263652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.