ReviewFrontiers in nutrition2025
Association of the dietary inflammation index with frailty in middle-aged and older adults: a systematic review and meta-analysis.
Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Article
- Dietary Patterns Influence Chronic Disease Risk and Health Outcomes in Older Adults: A Narrative Review.Nutrients · 2025Review
- The ratio of serum uric acid to high-density lipoprotein cholesterol as a predictor for frailty prevalence and mortality in the elderly U.S. adults.Lipids in health and disease · 2025Article
- Multifaceted Nutrition Intervention for Frail Elderly in the Community: Protocol of a Randomized Controlled Trial (The MINUTE Study).Nutrients · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Low-grade of chronic inflammation is a signature of the aging and physiologic frailty may be related to a dysfunctional homeostasis between pro- and anti-inflammatory systems mediated by diverse determinants, including dietary constituents that produce a wide range of biologically active substances, which are important modulators of inflammation in the organism. The Dietary Inflammation Index (DII), a quantitative measure of diet-associated inflammation, has been widely used in studies of a variety of chronic inflammation-related diseases, but the correlation between the DII and frailty has not been uniformly determined. Method: We searched multiple databases, including CNKI, Wanfang, VIP, Chinese Biomedical Literature Database, PubMed, Embase, Scopus, and Web of Science, to identify studies in English and Chinese examining the association between the dietary inflammatory index and frailty risk. Literature was searched from the time of database construction to January 2025. Two standardized scales were employed for quality assessment: NOS for longitudinal studies and AHRQ tools for cross-sectional research. Sensitivity analyses and publication bias tests were performed using Stata 15.0, and meta-analyses were performed using RevMan 5.3 to calculate the combined odds ratio (OR) and its 95% confidence interval (CI) to assess the DII in correlation with pre-frailty and frailty. Results: The meta-analysis examined 15 studies involving a total of 42,130 study participants. The combined results showed that individuals were at increased risk of both frailty [OR = 1.47, 95%CI (1.28, 1.69), Conclusions: Available evidence suggests that high pro-inflammatory diets may be associated with an increased risk of frailty, and that dietary strategies that lower the DII could play a role in reducing frailty incidence among older and middle-aged groups.
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Registered trials
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