ArticleFrontiers in nutrition2025
Association between insulin resistance-related lipid indices and arthritis: a U. S. cross-sectional study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Arthritis is a degenerative disease that causes a huge social burden. Lipid-related molecules participate in the inflammatory response process of arthritis and are closely related to the pathological process of arthritis. Lipid-related indicators are easily available and have great potential in predicting arthritis. This study used cross-sectional data to explore lipid-related indicators and arthritis risk. Methods: 18,683 participants were involved in this study, selected from the NHANES database covering the period from 2001 to 2018. The study utilized multivariate regression models to examine the association between various lipid-related parameters (including the TyG index, TyG-WC index, TyG-WHtR index, TyG-BMI index, HOMA-IR index, VAI index, and LAP index) and arthritis. Results: After taking into account and appropriately addressing potential confounding variables and factors, all seven lipid-related indicators were positively associated with arthritis risk, and there was a significant difference in the highest quartile of seven lipid-related indicators compared with the lowest quartile ( Conclusions: The results showed that seven lipid-related markers were positively associated with arthritis risk. Enhancing the management of glucose, lipids, and insulin sensitivity may significantly reduce the risk of arthritis.
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