Serum lipids, oxidative stress, and systemic inflammation mediate the association between circadian syndrome and periodontitis.

Background: Circadian rhythm disruption is an underlying cause of metabolic syndrome (MetS) and is associated with the development of periodontitis. Circadian syndrome (CircS) is an emerging measure of circadian rhythm disruption based on MetS. We aimed to explore the cross-sectional association between CircS and periodontitis through the National Health and Nutrition Examination Survey 2009-2014. Methods: We included 7,555 eligible participants. CircS was assessed by the five components of the MetS, depression, and short sleep duration, with fulfillment of ≥4 of the 7 components indicating the presence of CircS. Periodontitis was evaluated according to the Centers for Disease Control and Prevention-American Academy of Periodontology criteria. Multivariable logistic regression analysis was used to explore the association between CircS and periodontitis. In addition, restrictive cubic spline analysis, mediation analysis, and stratified analysis were used to comprehensively evaluate these associations. Results: After adjusting for all confounders, CircS was significantly associated with periodontitis (odds ratio 1.509, 95% CI 1.326-1.716, Conclusion: The presence of CircS was significantly associated with increased odds of periodontitis, serum lipids, oxidative stress, and systemic inflammation may mediate this association. These findings emphasize that CircS may serve as an independent risk factor for periodontitis and provide insights for individualized prevention of periodontitis.