ArticleFrontiers in genetics2025
Bioinformatics analysis and experimental validation of ferroptosis genes in heart failure and atrial fibrillation.
Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- IRF9-dependent transcriptional regulation of SLC40A1 suppresses ferroptosis in dilated cardiomyopathy.Scientific reports · 2026Article
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Authors and funding
6 authors.
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Abstract
Background and objectives: Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular diseases associated with significant morbidity and mortality in patients with both conditions. The objective of this research is to enhance our understanding of the shared pathogenesis underlying the two diseases and to identify novel therapeutic targets. Materials and methods: Differentially expressed genes (DEGs) in heart failure and atrial fibrillation were obtained through the analysis and comparison of transcriptional expression profiles from the Gene Expression Omnibus (GEO) datasets. By integrating these datasets with the known ferroptosis-related genes (FRGs) from GeneCards and PubMed, we identified ferroptosis-related differentially expressed genes (FRDEGs). Functional enrichment and the construction of the PPI network for key genes were conducted. The mRNA-miRNA and mRNA-TF Regulatory Network were constructed via the ChIPBase and TarBase databases. Receiver operating characteristic (ROC) was utilized to screen out the FRDEGs and validate their diagnostic values. Gene expression levels were detected by qPCR in patient serum samples. Results: By analyzing the transcriptional expression profiles of the GEO datasets, Conclusion: Our findings provide a theoretical basis for the clinical diagnosis and treatment of AF and HF. These results provide valuable insights into potential biomarkers for diagnosis and targets for therapeutic intervention in AF and HF.
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