Evidence map›Paper›PMID 40672306›Full record

ArticlebioRxiv : the preprint server for biology2025

Recruitment of Mre11 to recombination sites during meiosis.

Priyanka Priyadarshini, Mahesh Survi, Wael El Yazidi Mouloud, Regina Bohn, Steven Ballet, Neil Hunter, Alexander N Volkov, Corentin Claeys Bouuaert

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Priyanka PriyadarshiniLouvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, 1348 Louvain-La-Neuve, Belgium.ORCID 0000-0002-9564-9712
Mahesh SurviLouvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, 1348 Louvain-La-Neuve, Belgium.ORCID 0000-0003-2504-3069
Wael El Yazidi MouloudResearch Group of Organic Chemistry, Vrije Universiteit Brussel (VUB), Pleinlaan 2, 1050 Brussels, Belgium.
Regina BohnHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Steven BalletResearch Group of Organic Chemistry, Vrije Universiteit Brussel (VUB), Pleinlaan 2, 1050 Brussels, Belgium.
Neil HunterHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0003-1498-2327
Alexander N VolkovJean Jeener NMR Centre, Vrije Universiteit Brussel (VUB), Pleinlaan 2, 1050 Brussels, Belgium.ORCID 0000-0002-0103-059X
Corentin Claeys BouuaertLouvain Institute of Biomolecular Science and Technology, Université catholique de Louvain, 1348 Louvain-La-Neuve, Belgium.ORCID 0000-0001-5801-7313

Funding

Joint Molecule Resolution During Meiotic RecombinationR01GM074223 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI HUNTER, NEIL · 2005 to 2025
$6.0M
NIGMS NIH HHS R01 GM074223
6 · The paper itself

Abstract

The Mre11 nuclease, part of the conserved MRX complex involved in the repair of DNA double-strand breaks (DSBs), is also essential to initiate meiotic recombination in budding yeast by promoting Spo11-induced DSBs. Recruitment of Mre11 to meiotic DSB sites depends on Rec114-Mei4 and Mer2 (RMM) that organize the meiotic DSB machinery by a mechanism involving biomolecular condensation. Here, we explored the role of Mre11 during meiosis and its relationship to RMM condensation. We show that both Mre11 and MRX complexes form DNA-dependent, hexanediol sensitive condensates

Identifiers

PMID40672306
PMCPMC12265730

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.